OK, this one sounds really technical, but in all actuality it is not. In this webmaster video Matt Cutts answers the question:
If I use a ccTLD, can I indicate my geographic location is not in that country?
So what does this mean exactly? It means if you use a domain name like www.example.fr which is the extension for France, is it OK to use that domain in another region? This question has been coming up more and more. In this video Matt Cutt’s addresses this question. While he does say that it is an ongoing judgement call for Google (certain areas seem more generic and can have different interpretations), overall his response is no. So in light of this video below webmasters should, if at all possible, use a domain with the region specification you would like to target.